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Anti-MAG peripheral neuropathy : ウィキペディア英語版 | Anti-MAG peripheral neuropathy
Anti-MAG Peripheral Neuropathy is a specific type of peripheral neuropathy in which the person’s own immune system attacks cells that are specific in maintaining a healthy nervous system. As these cells are destroyed by antibodies, the nerve cells in the surrounding region begin to lose function and create many problems in both sensory and motor function. Specifically, antibodies against myelin-associated glycoprotein (MAG) damage Schwann cells. While the disorder occurs in only 10% of those afflicted with peripheral neuropathy, people afflicted have symptoms such as muscle weakness, sensory problems, and other motor deficits usually starting in the form of a tremor of the hands or trouble walking.〔Dalakas, M. C. (2010). Pathogenesis and Treatment of Anti-MAG Neuropathy. Current Treatment Options in Neurology, 12(2), 71-83. 〕〔Launay, M., Delmont, E., Benaim, C., Sacconi, S., Butori, C., & Desnuelle, C. (2009). Anti-MAG paraproteinemic demyelinating polyneuropathy: A clinical, biological, electrophysiological and anatomopathological descriptive study of a 13-patients' cohort. Revue Neurologique, 165(12), 1071-1079. 〕 There are, however, multiple treatments that range from simple exercises in order to build strength to targeted drug treatments that have been shown to improve function in people with this type of peripheral neuropathy.〔Gajos, A., Kielis, W., Szadkowska, I., Chmielowska, E., Niewodniczy, A., & Bogucki, A. (2007). Acquired peripheral neuropathies associated with monoclonal gammopathy. Neurologia I Neurochirurgia Polska, 41(2), 169-175.〕 ==Background==
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